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Autologous dermal fibroblasts for the correction of age-related skin changes (SPRS-therapy®). Results of 2-year clinical trials and post-marketing clinical studies

One of the innovative methods to correct the age-related skin changes is the use of cultured fibroblasts derived from the patient's own skin. The technology called SPRS-therapy® (Service for Personal Regeneration of Skin) has been officially approved in 2011 in Russia (developed by the public biotech company Human Stem Cells Institute (HSCI), Moscow). The results of two-year clinical trials with the application of SPRS-therapy to correct the agerelated skin defects demonstrated, that after the intradermal transplantation (injections), cultivated autoDF (autologous dermal fibroblasts) fully integrated into the dermis and their biosynthetic activity maintained at least for 12 months. As a result, the increase of collagen content and skin hydration was observed as well as the increased thickness of the dermis. The abovementioned changes resulted in the increase of skin tension, elasticity, and thickness and in the decrease of an amount of wrinkles and their depth. The results of post-marketing studies conducted by HSCI after the first year of the application of technology in clinics confirmed the safety and clinical efficacy of SPRS-therapy for correction of skin aging changes.

Autologous dermal fibroblasts for the correction of age-related skin changes (SPRS-therapy®). Results of 2-year clinical trials and post-marketing clinical studies
CellR4 2016; 4 (3): e2084

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